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Association of Antidepressant Medication Use During Pregnancy With Intellectual Disability in Offspring
Alexander Viktorin, PhD ; Rudolf Uher, MD, PhD; Alexander Kolevzon, MD1,2; et al Abraham Reichenberg, PhD; Stephen Z. Levine, PhD; Sven Sandin, PhD
JAMA Psychiatry. Published online July 12, 2017.
Question Does maternal antidepressant medication use during pregnancy increase the risk of intellectual disability in offspring?
Findings In this population-based cohort study of 179 007 pregnancies, an association of maternal antidepressant medication use during pregnancy with intellectual disability in offspring was attenuated when parental factors other than medication use were taken into account.
Meaning An elevated risk of intellectual disability in children born to women who used antidepressant medication during pregnancy is likely attributable to factors underlying the treatment and not to the antidepressant medication itself.