Глютен: есть или не есть?

Если у вас нет целиакии (а ее только врач устанавливает), то ешьте глютен в свое удовольствие!
Ну или не ешьте если не в удовольствие - ваше дело.
Но бла-бла про непереносимость глютена - это самовнушение по типу метеочувствительности и прочих а-ля ноцебо эффектов!!

N.S.

Gastroenterology. 2013 Aug;145(2):320-8.e1-3. doi: 10.1053/j.gastro.2013.04.051. Epub 2013 May 4.

No effects of gluten in patients with self-reported non-celiac gluten sensitivity after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates.

Biesiekierski JR, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR

Abstract

BACKGROUND & AIMS:

Patients with non-celiac gluten sensitivity (NCGS) do not have celiac disease but their symptoms improve when they are placed on gluten-free diets. We investigated the specific effects of gluten after dietary reduction of fermentable, poorly absorbed, short-chain carbohydrates (fermentable, oligo-, di-, monosaccharides, and polyols [FODMAPs]) in subjects believed to have NCGS.

METHODS:

We performed a double-blind cross-over trial of 37 subjects (aged 24-61 y, 6 men) with NCGS and irritable bowel syndrome (based on Rome III criteria), but not celiac disease. Participants were randomly assigned to groups given a 2-week diet of reduced FODMAPs, and were then placed on high-gluten (16 g gluten/d), low-gluten (2 g gluten/d and 14 g whey protein/d), or control (16 g whey protein/d) diets for 1 week, followed by a washout period of at least 2 weeks. We assessed serum and fecal markers of intestinal inflammation/injury and immune activation, and indices of fatigue. Twenty-two participants then crossed over to groups given gluten (16 g/d), whey (16 g/d), or control (no additional protein) diets for 3 days. Symptoms were evaluated by visual analogue scales.

RESULTS:

In all participants, gastrointestinal symptoms consistently and significantly improved during reduced FODMAP intake, but significantly worsened to a similar degree when their diets included gluten or whey protein. Gluten-specific effects were observed in only 8% of participants. There were no diet-specific changes in any biomarker. During the 3-day rechallenge, participants' symptoms increased by similar levels among groups. Gluten-specific gastrointestinal effects were not reproduced. An order effect was observed.

CONCLUSIONS:

In a placebo-controlled, cross-over rechallenge study, we found no evidence of specific or dose-dependent effects of gluten in patients with NCGS placed diets low in FODMAPs.

Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Abdominal Pain; Clinical Trial; D-FIS; Daily-Fatigue Impact Scale; FODMAP; Food Allergy; GFD; IBS; NCGS; VAS; Wheat; fermentable, oligo-, di-, monosaccharides, and polyols; gluten-free diet; irritable bowel syndrome; non-celiac gluten sensitivity; visual analogue scale

Comment in

• Gluten sensitivity: not celiac and not certain. [Gastroenterology. 2013]
• Reply: To PMID 23648697. [Gastroenterology. 2014]
• Non-celiac wheat sensitivity is a more appropriate label than non-celiac gluten sensitivity. [Gastroenterology. 2014]

PMID:

 

23648697

 

DOI:

 

10.1053/j.gastro.2013.04.051