разные исследования разных лет и темы
2015-07-17 20:33:00
Antidepressant/NSAID Combo Linked to Brain Bleed Risk
Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans
Jennifer L. Warner-Schmidt, Kimberly E. Vanover, Emily Y. Chen, John J. Marshall, and Paul Greengarda
Proc Natl Acad Sci U S A. May 31, 2011; 108(22): 9262–9267.
Published online Apr 25, 2011. doi: 10.1073/pnas.1104836108
PMCID: PMC3107316
ABSTRACT
Antiinflammatory drugs achieve their therapeutic actions at least in part by regulation of cytokine formation. A “cytokine hypothesis” of depression is supported by the observation that depressed individuals have elevated plasma levels of certain cytokines compared with healthy controls. Here we investigated a possible interaction between antidepressant agents and antiinflammatory agents on antidepressant-induced behaviors and on p11, a biochemical marker of depressive-like states and antidepressant responses. We found that widely used antiinflammatory drugs antagonize both biochemical and behavioral responses to selective serotonin reuptake inhibitors (SSRIs). In contrast to the levels detected in serum, we found that frontal cortical levels of certain cytokines (e.g., TNFα and IFNγ) were increased by serotonergic antidepressants and that these effects were inhibited by antiinflammatory agents. The antagonistic effect of antiinflammatory agents on antidepressant-induced behaviors was confirmed by analysis of a dataset from a large-scale real-world human study, “sequenced treatment alternatives to relieve depression” (STAR*D), underscoring the clinical significance of our findings. Our data indicate that clinicians should carefully balance the therapeutic benefits of antiinflammatory agents versus the potentially negative consequences of antagonizing the therapeutic efficacy of antidepressant agents in patients suffering from depression.
Free full text
2013-07-26 17:21:00
КПТ посредством компьютера при депрессии у взрослых - метанализ
2012-07-21 23:03:00
http://www.emea.europa.eu/ema/index.jsp?c
"Doctors should no longer prescribe trimetazidine for the treatment of patients with tinnitus, vertigo or disturbances in vision.
Doctors can continue to prescribe trimetazidine for the treatment of angina pectoris, but only as an add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled by or intolerant to first-line anti-anginal therapies.
Doctors are advised not to prescribe the medicine to patients with Parkinson's disease, Parkinsonian symptoms, tremors, restless-leg syndrome or other related movement disorders, nor to patients with severe renal impairment.
Doctors should exercise caution when prescribing trimetazidine to patients with moderate renal impairment and to elderly patients, and consider dose reduction in these patients." (с)
P.S. В РФ наиболее распространен триметазидин под торговыми марками Предуктал (R), Предизин(R), Тримектал(R), Депренорм(R) и др.
2012 - 06 - 15 23:44:00
2010 - 08 - 09 17:09:00
Mother's affection at 8 months predicts emotional distress in adulthood.
J Epidemiol Community Health. 2010 Jul 26
Maselko J, Kubzansky L, Lipsitt L, Buka SL.
Durham, North Carolina, USA.
Abstract
Background Long-standing theory suggests that quality of the mother's (or primary caregiver's) interaction with a child is a key determinant of the child's subsequent resilience or vulnerability and has implications for health in adulthood. However, there is a dearth of longitudinal data with both objective assessments of nurturing behaviour during infancy and sustained follow-up ascertaining the quality of adult functioning. Methods We used data from the Providence, Rhode Island birth cohort of the National Collaborative Perinatal Project (mean age 34 at follow-up, final N=482) to conduct a prospective study of the association between objectively measured affective quality of the mother-infant interaction and adult mental health. Infant-mother interaction quality was rated by an observer when infants were 8 months old, and adult emotional functioning was assessed from the Symptom Checklist-90, capturing both specific and general types of distress. Results High levels of maternal affection at 8 months were associated with significantly lower levels of distress in adult offspring (1/2 standard deviation; b=-4.76, se=1.7, p<0.01). The strongest association was with the anxiety subscale. Mother's affection did not seem to be on the pathway between lower parental SES and offspring distress. Conclusion These findings suggest that early nurturing and warmth have long-lasting positive effects on mental health well into adulthood.
PMID: 20660942 [PubMed - as supplied by publisher]
medscape.com
Children With Autism Routinely Exhibit Feeding Difficulties in Infanc
Deborah Brauser, Journalist (is a freelance writer for Medscape).
July 28, 2010 — Although children with autism spectrum disorders (ASDs) exhibit feeding symptoms as early as 6 months of age and have a less varied diet than healthy children after 15 months of age, these eating patterns do not impair their energy intake and/or growth, according to a new comparison study of almost 13,000 children from the United Kingdom.
Рediatrics. Published online July 19, 2010
medscape.com
2010-07-05 23:17:00
Dr Annelieke M Roest (Нидерланды) и его коллеги провели метанализ двадцати исследований. В общей сложности включены были 250 000 изначально здоровых людей из Соединенных Штатов, Норвегии, Нидерландов, Швеции, Японии и Великобритании. Длительность наблюдения - более 11 лет. Конечные точки - сердечная смертности или ИМ. В 18 исследований из 20 выявлено что тревожные люди подвергаются более высокому риску ИБС.
http://cme.medscape.com/viewarticle/724
P.S. Тревога, но не депрессия.
2010-04-17 10:28:00
Suicidal Risks Comparable for Different Antidepressant Agents
April 12, 2010 — When initiating antidepressant therapy in children and adolescents, there appears to be no clinically meaningful variation in the risk for suicidal acts by antidepressant agent within the class of serotonin reuptake inhibitors (SSRIs) or among different classes of antidepressant.
These findings are from a 9-year cohort study published online April 12 and appearing in the May issue of Pediatrics
www.medscape.com/viewarticle/720122
Standardized Screening May Help Identify Suicidal Adolescents
April 15, 2010 — Standardized screening for suicide risk in primary care can detect adolescents with suicidal ideation, allowing referral to a behavioral healthcare center before a fatal or serious suicide attempt is made, according to the results of a study reported online April 12 and published in the May print issue of Pediatric
www.medscape.com/viewarticle/720298
2010-04-12 13:10:00
Результаты мега-анализа позволяют предположить, что комбинированная терапия более эффективна, чем фармакотерапия. Краткосрочная психодинамическая поддерживающая психотерапия и фармакотерапия представляются одинаково эффективными, при этом пациенты и врачи отмечали лучше редукцию симптомов при психотерапии. Комбинированная терапия и краткосрочная психодинамическая поддерживающая психотерапия также представляются одинаково эффективными, но пациенты считают, что первая лучше в редукции симптомов.
2010-04-07 11:07:00
Are psychological and pharmacologic interventions equally effective in the treatment of adult depressive disorders? A meta-analysis of comparative studies.
J Clin Psychiatry. 2008 Nov;69(11):1675-85; quiz 1839-41. Epub 2009 Jan 17.
4 ноя, 2009 в 20:49
2015-07-17 20:33:00
Antidepressant/NSAID Combo Linked to Brain Bleed Risk
The combination of antidepressants and nonsteroidal anti-inflammatory drugs (NSAIDS) is linked to an early increased risk for intracranial hemorrhage, regardless of the type of NSAID or antidepressant, new research shows.
"The take-home message for clinicians is that special attention should be paid [to] antidepressant users when they start an NSAID prescription," coauthor Byung-Joo Park, MD, MPH, PhD, told Medscape Medical News.
"Monitoring bleeding risk is particularly needed at the initial combined use of both medicines," added Dr Park, who is a professor in the Seoul National University College of Medicine's Department of Preventive Medicine, in Korea.
The study was published online July 14 in the BMJ.
"The take-home message for clinicians is that special attention should be paid [to] antidepressant users when they start an NSAID prescription," coauthor Byung-Joo Park, MD, MPH, PhD, told Medscape Medical News.
"Monitoring bleeding risk is particularly needed at the initial combined use of both medicines," added Dr Park, who is a professor in the Seoul National University College of Medicine's Department of Preventive Medicine, in Korea.
The study was published online July 14 in the BMJ.
2015-01-27 12:33:00
НПВС уменьшают эффективность СИОЗС
Jennifer L. Warner-Schmidt, Kimberly E. Vanover, Emily Y. Chen, John J. Marshall, and Paul Greengarda
Proc Natl Acad Sci U S A. May 31, 2011; 108(22): 9262–9267.
Published online Apr 25, 2011. doi: 10.1073/pnas.1104836108
PMCID: PMC3107316
ABSTRACT
Antiinflammatory drugs achieve their therapeutic actions at least in part by regulation of cytokine formation. A “cytokine hypothesis” of depression is supported by the observation that depressed individuals have elevated plasma levels of certain cytokines compared with healthy controls. Here we investigated a possible interaction between antidepressant agents and antiinflammatory agents on antidepressant-induced behaviors and on p11, a biochemical marker of depressive-like states and antidepressant responses. We found that widely used antiinflammatory drugs antagonize both biochemical and behavioral responses to selective serotonin reuptake inhibitors (SSRIs). In contrast to the levels detected in serum, we found that frontal cortical levels of certain cytokines (e.g., TNFα and IFNγ) were increased by serotonergic antidepressants and that these effects were inhibited by antiinflammatory agents. The antagonistic effect of antiinflammatory agents on antidepressant-induced behaviors was confirmed by analysis of a dataset from a large-scale real-world human study, “sequenced treatment alternatives to relieve depression” (STAR*D), underscoring the clinical significance of our findings. Our data indicate that clinicians should carefully balance the therapeutic benefits of antiinflammatory agents versus the potentially negative consequences of antagonizing the therapeutic efficacy of antidepressant agents in patients suffering from depression.
Free full text
2013-07-26 17:21:00
КПТ посредством компьютера при депрессии у взрослых - метанализ
Is computerised CBT really helpful for adult depression?-A meta-analytic re-evaluation of CCBT for adultdepression in terms of clinical implementation and methodological validity.
Source
Department of Psychological Medicine, Institute of Psychiatry, Kings College London, UK
Abstract
BACKGROUND:
Depression is a major cause of disability worldwide, and computerised cognitive behavioural therapy (CCBT) is expected to be a more augmentative and efficient treatment. According to previous meta-analyses of CCBT, there is a need for a meta-analytic revaluation of the short-term effectiveness of this therapy and for an evaluation of its long-term effects, functional improvement and dropout.
METHODS:
Five databases were used (MEDLINE, PsycINFO, EMBASE, CENTRAL and CiNii). We included all RCTs with proper concealment and blinding of outcome assessment for the clinical effectiveness of CCBT in adults (aged 18 and over) with depression. Using Cohen's method, the standard mean difference (SMD) for the overall pooled effects across the included studies was estimated with a random effect model. The main outcome measure and the relative risk of dropout were included in the meta-analysis.
RESULTS:
Fourteen trials met the inclusion criteria, and sixteen comparisons from these were used for the largest meta-analysis ever. All research used appropriate random sequence generation and Intention-to-Treat analyses (ITT), and employed self-reported measures as the primary outcome. For the sixteen comparisons (2807 participants) comparing CCBT and control conditions, the pooled SMD was -0.48 [95% IC -0.63 to -0.33], suggesting similar effect to the past reviews. Also, there was no significant clinical effect at long follow-up and no improvement of function found. Furthermore, a significantly higher drop-out rate was found for CCBT than for controls. When including studies without BDI as a rating scale and with only modern imputation as sensitivity analysis, the pooled SMD remained significant despite the reduction from a moderate to a small effect. Significant publication bias was found in a funnel plot and on two tests (Begg's p = 0.09; Egger's p = 0.01). Using a trim and fill analysis, the SMD was -0.32 [95% CI -0.49 to -0.16].
CONCLUSION:
Despite a short-term reduction in depression at post-treatment, the effect at long follow-up and the function improvement were not significant, with significantly high drop-out. Considering the risk of bias, our meta-analysis implied that the clinical usefulness of current CCBT for adult depression may need to be re-considered downwards in terms of practical implementation and methodological validity.
2012-07-21 23:03:00
Триметазидин - давай, до свидания!
European Medicines Agency recommends restricting use of trimetazidine-containing medicineshttp://www.emea.europa.eu/ema/index.jsp?c
"Doctors should no longer prescribe trimetazidine for the treatment of patients with tinnitus, vertigo or disturbances in vision.
Doctors can continue to prescribe trimetazidine for the treatment of angina pectoris, but only as an add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled by or intolerant to first-line anti-anginal therapies.
Doctors are advised not to prescribe the medicine to patients with Parkinson's disease, Parkinsonian symptoms, tremors, restless-leg syndrome or other related movement disorders, nor to patients with severe renal impairment.
Doctors should exercise caution when prescribing trimetazidine to patients with moderate renal impairment and to elderly patients, and consider dose reduction in these patients." (с)
P.S. В РФ наиболее распространен триметазидин под торговыми марками Предуктал (R), Предизин(R), Тримектал(R), Депренорм(R) и др.
2012 - 06 - 15 23:44:00
Effect of Telephone-Administered vs Face-to-face Cognitive Behavioral Therapy on Adherence to Therapy and Depression Outcomes Among Primary Care PatientsA Randomized Trial
David C. Mohr, PhD; Joyce Ho, PhD; Jenna Duffecy, PhD; Douglas Reifler, MD; Leslie Sokol, PhD; Michelle Nicole Burns, PhD; Ling Jin, MS; Juned Siddique, DrPH
JAMA . 2012; 307 (21) :2278-2285. DOI: 10.1001/jama.2012.5588
Context Primary care is the most common site for the treatment of depression. Most depressed patients prefer psychotherapy over antidepressant medications, but access barriers are believed to prevent engagement in and completion of treatment. The telephone has been investigated as a treatment delivery medium to overcome access barriers, but little is known about its efficacy compared with face-to-face treatment delivery.
David C. Mohr, PhD; Joyce Ho, PhD; Jenna Duffecy, PhD; Douglas Reifler, MD; Leslie Sokol, PhD; Michelle Nicole Burns, PhD; Ling Jin, MS; Juned Siddique, DrPH
JAMA . 2012; 307 (21) :2278-2285. DOI: 10.1001/jama.2012.5588
Context Primary care is the most common site for the treatment of depression. Most depressed patients prefer psychotherapy over antidepressant medications, but access barriers are believed to prevent engagement in and completion of treatment. The telephone has been investigated as a treatment delivery medium to overcome access barriers, but little is known about its efficacy compared with face-to-face treatment delivery.
Objective To examine whether telephone-administered cognitive behavioral therapy (T-CBT) reduces attrition and is not inferior to face-to-face CBT in treating depression among primary care patients.
Design, Setting, and Participants A randomized controlled trial of 325 Chicago-area primary care patients with major depressive disorder, recruited from November 2007 to December 2010.
Interventions Eighteen sessions of T-CBT or face-to-face CBT.
Main Outcome Measures The primary outcome was attrition (completion vs noncompletion) at posttreatment (week 18). Secondary outcomes included masked interviewer-rated depression with the Hamilton Depression Rating Scale (Ham-D) and self-reported depression with the Patient Health Questionnaire–9 (PHQ-9).
Results Significantly fewer participants discontinued T-CBT (n = 34; 20.9%) compared with face-to-face CBT (n = 53; 32.7%; P = .02). Patients showed significant improvement in depression across both treatments (P < .001). There were no significant treatment differences at posttreatment between T-CBT and face-to-face CBT on the Ham-D (P = .22) or the PHQ-9 (P = .89). The intention-to-treat posttreatment effect size on the Ham-D was d = 0.14 (90% CI, −0.05 to 0.33), and for the PHQ-9 it was d = −0.02 (90% CI, −0.20 to 0.17). Both results were within the inferiority margin ofd = 0.41, indicating that T-CBT was not inferior to face-to-face CBT. Although participants remained significantly less depressed at 6-month follow-up relative to baseline (P < .001), participants receiving face-to-face CBT were significantly less depressed than those receiving T-CBT on the Ham-D (difference, 2.91; 95% CI, 1.20-4.63; P < .001) and the PHQ-9 (difference, 2.12; 95% CI, 0.68-3.56;P = .004).
Conclusions Among primary care patients with depression, providing CBT over the telephone compared with face-to-face resulted in lower attrition and close to equivalent improvement in depression at posttreatment. At 6-month follow-up, patients remained less depressed relative to baseline; however, those receiving face-to-face CBT were less depressed than those receiving T-CBT. These results indicate that T-CBT improves adherence compared with face-to-face delivery, but at the cost of some increased risk of poorer maintenance of gains after treatment cessation.
http://jama.jamanetwork.com/article.aspx?a
http://jama.jamanetwork.com/article.aspx?a
2010 - 08 - 09 17:09:00
Mother's affection at 8 months predicts emotional distress in adulthood.
J Epidemiol Community Health. 2010 Jul 26
Maselko J, Kubzansky L, Lipsitt L, Buka SL.
Durham, North Carolina, USA.
Abstract
Background Long-standing theory suggests that quality of the mother's (or primary caregiver's) interaction with a child is a key determinant of the child's subsequent resilience or vulnerability and has implications for health in adulthood. However, there is a dearth of longitudinal data with both objective assessments of nurturing behaviour during infancy and sustained follow-up ascertaining the quality of adult functioning. Methods We used data from the Providence, Rhode Island birth cohort of the National Collaborative Perinatal Project (mean age 34 at follow-up, final N=482) to conduct a prospective study of the association between objectively measured affective quality of the mother-infant interaction and adult mental health. Infant-mother interaction quality was rated by an observer when infants were 8 months old, and adult emotional functioning was assessed from the Symptom Checklist-90, capturing both specific and general types of distress. Results High levels of maternal affection at 8 months were associated with significantly lower levels of distress in adult offspring (1/2 standard deviation; b=-4.76, se=1.7, p<0.01). The strongest association was with the anxiety subscale. Mother's affection did not seem to be on the pathway between lower parental SES and offspring distress. Conclusion These findings suggest that early nurturing and warmth have long-lasting positive effects on mental health well into adulthood.
PMID: 20660942 [PubMed - as supplied by publisher]
medscape.com
Children With Autism Routinely Exhibit Feeding Difficulties in Infanc
Deborah Brauser, Journalist (is a freelance writer for Medscape).
July 28, 2010 — Although children with autism spectrum disorders (ASDs) exhibit feeding symptoms as early as 6 months of age and have a less varied diet than healthy children after 15 months of age, these eating patterns do not impair their energy intake and/or growth, according to a new comparison study of almost 13,000 children from the United Kingdom.
Рediatrics. Published online July 19, 2010
medscape.com
2010-07-05 23:17:00
Тревога - предикт ССЗ
http://cme.medscape.com/viewarticle/724
P.S. Тревога, но не депрессия.
2010-04-17 10:28:00
Suicidal Risks Comparable for Different Antidepressant Agents
April 12, 2010 — When initiating antidepressant therapy in children and adolescents, there appears to be no clinically meaningful variation in the risk for suicidal acts by antidepressant agent within the class of serotonin reuptake inhibitors (SSRIs) or among different classes of antidepressant.
These findings are from a 9-year cohort study published online April 12 and appearing in the May issue of Pediatrics
www.medscape.com/viewarticle/720122
Standardized Screening May Help Identify Suicidal Adolescents
April 15, 2010 — Standardized screening for suicide risk in primary care can detect adolescents with suicidal ideation, allowing referral to a behavioral healthcare center before a fatal or serious suicide attempt is made, according to the results of a study reported online April 12 and published in the May print issue of Pediatric
www.medscape.com/viewarticle/720298
2010-04-12 13:10:00
Краткосрочная психодинамическая поддерживающая психотерапия и антидепрессанты в лечении депресии
Результаты мега-анализа позволяют предположить, что комбинированная терапия более эффективна, чем фармакотерапия. Краткосрочная психодинамическая поддерживающая психотерапия и фармакотерапия представляются одинаково эффективными, при этом пациенты и врачи отмечали лучше редукцию симптомов при психотерапии. Комбинированная терапия и краткосрочная психодинамическая поддерживающая психотерапия также представляются одинаково эффективными, но пациенты считают, что первая лучше в редукции симптомов.
Short psychodynamic supportive psychotherapy, antidepressants, and their combination in the treatment of major depression: a mega-analysis based on three randomized clinical trials.
de Maat S, Dekker J, Schoevers R, van Aalst G, Gijsbers-van Wijk C, Hendriksen M, Kool S, Peen J, Van R, de Jonghe F.
Depression Research Group of the Mentrum Institute for Mental Health, Free University, Amsterdam, The Netherlands.
Depress Anxiety. 2008;25(7):565-74.
Depress Anxiety. 2008;25(7):565-74.
Abstract
The efficacy of Short Psychodynamic Supportive Psychotherapy (SPSP) has not yet been compared with pharmacotherapy. A mega-analysis based on three original Randomized Clinical Trials (RCTs) was performed. Patients with (mild to moderate) major depressive disorder were randomized in (24 weeks) SPSP (n = 97), pharmacotherapy (n = 45), or their combination (n = 171). Efficacy was assessed by the Hamilton Depression Rating Scale (HDRS), Clinical Global Impression of Severity and of Improvement (CGI-S), the Symptom Checklist (SCL; depression subscale) and the Quality of Life Depression Scale (QLDS). Pearson chi(2) calculations were used to compare success rates. Analyses of covariance (ANCOVAs) were used to test inter-group differences. Success rates indicated that independent observers (HDRS) found no differences in symptom reduction between SPSP and pharmacotherapy (P = 0.214), but therapists (CGI-S, P = 0.026), and patients (SCL, P = 0.036) favored SPSP. Combined therapy was found superior to pharmacotherapy by all three (patients (P = 0.000), therapists (P = 0.024), independent observers (P = 0.024)). Independent observers (P = 0.062) and therapists (P = 0.430) found no differences between combined therapy and SPSP, but patients (P = 0.016) found combined therapy to be superior. As far as quality of life is concerned, success rates indicated that patients (QLDS) found no differences between SPSP and pharmacotherapy (P = 0.073) or between SPSP and combined therapy (P = 0.217). However, they found combined therapy superior to pharmacotherapy (P = 0.015). The results of the mega-analysis suggest that combined therapy is more efficacious than pharmacotherapy. SPSP and pharmacotherapy seem equally efficacious, except for some indications that patients and therapists favor SPSP for symptom reduction. Combined therapy and SPSP also seem equally efficacious, except that patients think that the first is better in symptom reduction.
PMID: 17557313 [PubMed - indexed for MEDLINE]
2010-04-07 11:07:00
Are psychological and pharmacologic interventions equally effective in the treatment of adult depressive disorders? A meta-analysis of comparative studies.
J Clin Psychiatry. 2008 Nov;69(11):1675-85; quiz 1839-41. Epub 2009 Jan 17.
Abstract
OBJECTIVE: A large number of studies suggest that both psychological and pharmacologic therapies are effective in the treatment of mild-to-moderate depressive disorders. Whether both types of intervention are equally effective has not been established definitively. DATA SOURCES: A database was developed through a comprehensive literature search (from 1966 to May 2007) in which 6947 abstracts in PubMed (1244 abstracts), PsycINFO (1736), EMBASE (1911), and the Cochrane Central Register of Controlled Trials (2056) were examined. Abstracts were identified by combining terms indicative of psychological treatment and depression (both MeSH terms and text words). For this database, the primary studies from 22 meta-analyses of psychological treatment for depression were also collected. STUDY SELECTION: For the current study, the abstracts of 832 studies were examined. DATA EXTRACTION: Thirty randomized trials were included in a meta-analysis that compared the effects of a psychological treatment for 3178 adults with a diagnosed depressive disorder (major depressive disorder, dysthymia, minor depressive disorder) with the effects of a pharmacologic treatment. DATA SYNTHESIS: In studies of patients with dysthymia, pharmacotherapy was significantly more effective than psychotherapy (d = -0.28, 95% CI = -0.47 to -0.10). In patients with major depressive disorder, treatments with selective serotonin reuptake inhibitors (SSRIs) were significantly more effective than psychological treatments, while treatment with other antidepressants did not differ significantly. Subgroup and metaregression analyses did not show that pretest severity of depressive symptoms was associated with differential effects of psychological and pharmacologic treatments of major depressive disorder. Dropout rates were smaller in psychological interventions compared with pharmacologic treatments (odds ratio = 0.66, 95% CI = 0.47 to 0.92). CONCLUSIONS: Pharmacologic treatments may be more effective than psychological interventions in the treatment of dysthymia. Pharmacologic treatment with SSRIs may also be more effective in the treatment of major depressive disorder, although these differences are small and probably have little meaning from a clinical point of view. We can conclude that both psychological and pharmacologic therapies are effective in the treatment of depressive disorders and that each has its own merits. Copyright 2008 Physicians Postgraduate Press, Inc.
PMID: 18945396 [PubMed - indexed for MEDLINE]
4 ноя, 2009 в 20:49
The Efficacy of an Internet-based Cognitive-behavioral Therapy Intervention for Child Anxiety Disorders
Sonja March, B Psych Hons; Susan H. Spence, PhD, MBA; Caroline L. Donovan, PhD
From Journal of Pediatric Psychology
Published: 10/23/2009
Published: 10/23/2009
Abstract
Objective: To evaluate the efficacy of an Internet-based cognitive-behavioral therapy (CBT) approach to the treatment of child anxiety disorders.
Methods: Seventy-three children with anxiety disorders, aged 7-12 years, and their parents were randomly assigned to either an Internet-based CBT (NET) or wait-list (WL) condition. Clinical diagnostic assessment and parent and child questionnaires were completed before and after treatment. The NET condition was reassessed at 6-month follow-up.
Results: At posttreatment assessment, children in the NET condition showed small but significantly greater reductions in anxiety symptoms and increases in functioning than WL participants. These improvements were enhanced during the 6-month follow-up period, with 75% of NET children free of their primary diagnosis.
Conclusions: Internet delivery of CBT for child anxiety offers promise as a way of increasing access to treatment for this population. Future research is needed to examine ways to increase treatment compliance and further enhance the impact of treatment.
(с) http://www.medscape.com/viewarticle/7102
Methods: Seventy-three children with anxiety disorders, aged 7-12 years, and their parents were randomly assigned to either an Internet-based CBT (NET) or wait-list (WL) condition. Clinical diagnostic assessment and parent and child questionnaires were completed before and after treatment. The NET condition was reassessed at 6-month follow-up.
Results: At posttreatment assessment, children in the NET condition showed small but significantly greater reductions in anxiety symptoms and increases in functioning than WL participants. These improvements were enhanced during the 6-month follow-up period, with 75% of NET children free of their primary diagnosis.
Conclusions: Internet delivery of CBT for child anxiety offers promise as a way of increasing access to treatment for this population. Future research is needed to examine ways to increase treatment compliance and further enhance the impact of treatment.
(с) http://www.medscape.com/viewarticle/7102
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